MetaDome through GeneFoundry

Explore protein tolerance landscapes and domain context for a resolved MetaDome transcript.

Research area
Genes & proteins
Namespace
metadome
Listed tools
11
Upstream source
MetaDome

Research tasks

  • Resolve a gene to an analyzable transcript
  • Inspect residue tolerance and homologous domain context

Start with tool discovery

The catalog lists metadome_resolve_transcript as a representative tool. After connecting your client, inspect the tools and input requirements returned by the service before submitting a query.

Identifiers to prepare

  • Gene symbol
  • Versioned Ensembl transcript identifier

Source version not supplied by this website catalog.

All available tools (11)

The router surfaces these tools namespaced under metadome_*:

get_server_capabilitiesSignature: get_server_capabilities(detail=, response_mode=).

Router invocation: metadome_get_server_capabilities()

Signature: get_server_capabilities(detail=, response_mode=).

Input parameters

  • detail(any) — Detail level.
  • response_mode(any) — Mode.
get_diagnosticsSignature: get_diagnostics(response_mode=).

Router invocation: metadome_get_diagnostics()

Signature: get_diagnostics(response_mode=).

Input parameters

  • response_mode(any) — Mode.
resolve_transcriptSignature: resolve_transcript(query, response_mode=).

Router invocation: metadome_resolve_transcript()

Signature: resolve_transcript(query, response_mode=).

Input parameters

  • query(string) [required] — Query.
  • response_mode(any) — Mode.
request_tolerance_landscapeSignature: request_tolerance_landscape(transcript_id, response_mode=).

Router invocation: metadome_request_tolerance_landscape()

Signature: request_tolerance_landscape(transcript_id, response_mode=).

Input parameters

  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
get_tolerance_landscapeSignature: get_tolerance_landscape(transcript_id, position_start=, position_stop=, limit=, offset=, response_mode=).

Router invocation: metadome_get_tolerance_landscape()

Signature: get_tolerance_landscape(transcript_id, position_start=, position_stop=, limit=, offset=, response_mode=).

Input parameters

  • limit(integer) — Limit.
  • offset(integer) — Offset.
  • position_start([ "integer", "null" ]) — Pos.
  • position_stop([ "integer", "null" ]) — Pos.
  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
get_position_toleranceSignature: get_position_tolerance(transcript_id, position, response_mode=).

Router invocation: metadome_get_position_tolerance()

Signature: get_position_tolerance(transcript_id, position, response_mode=).

Input parameters

  • position(integer) [required] — Pos.
  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
get_variant_countsSignature: get_variant_counts(transcript_id, position=, position_start=, position_stop=, source=, limit=, offset=, response_mode=).

Router invocation: metadome_get_variant_counts()

Signature: get_variant_counts(transcript_id, position=, position_start=, position_stop=, source=, limit=, offset=, response_mode=).

Input parameters

  • limit(integer) — Limit.
  • offset(integer) — Offset.
  • position([ "integer", "null" ]) — Pos.
  • position_start([ "integer", "null" ]) — Pos.
  • position_stop([ "integer", "null" ]) — Pos.
  • response_mode(any) — Mode.
  • source(any) — Source.
  • transcript_id(string) [required] — ENST.
compare_positionsSignature: compare_positions(transcript_id, positions, response_mode=).

Router invocation: metadome_compare_positions()

Signature: compare_positions(transcript_id, positions, response_mode=).

Input parameters

  • positions(array) [required] — Residues.
  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
get_protein_domainsSignature: get_protein_domains(transcript_id, response_mode=).

Router invocation: metadome_get_protein_domains()

Signature: get_protein_domains(transcript_id, response_mode=).

Input parameters

  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
get_meta_domainSignature: get_meta_domain(transcript_id, position, domains=, limit=, offset=, response_mode=).

Router invocation: metadome_get_meta_domain()

Signature: get_meta_domain(transcript_id, position, domains=, limit=, offset=, response_mode=).

Input parameters

  • domains(any) — Pfam selector.
  • limit(integer) — Limit.
  • offset(integer) — Offset.
  • position(integer) [required] — Pos.
  • response_mode(any) — Mode.
  • transcript_id(string) [required] — ENST.
summarize_intolerant_regionsSignature: summarize_intolerant_regions(transcript_id, threshold=, min_run=, top_n=, response_mode=).

Router invocation: metadome_summarize_intolerant_regions()

Signature: summarize_intolerant_regions(transcript_id, threshold=, min_run=, top_n=, response_mode=).

Input parameters

  • min_run(integer) — Run length.
  • response_mode(any) — Mode.
  • threshold(number) — Cutoff.
  • top_n(integer) — Region count.
  • transcript_id(string) [required] — ENST.

Database & release provenance

Data mode
none
Attestation
unhosted
Release version
v0.3.7
Container image:ghcr.io/berntpopp/metadome-link@sha256:9a9cfe6fb02d2b8b374983687f882e7f7fffe575f959355df5cab7dc671f9e80

Inspect canonical provenance artifact: genefoundry.org/provenance (JSON)

Review the response

Keep the source record link and submitted identifiers with your notes. Record the dataset version and retrieval date when available. This page does not contain a captured MetaDome response.

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