Biomedical databases in your AI chat.

Look up genes, compare variant records and explore phenotype associations. Use GeneFoundry from Claude, ChatGPT or another MCP client.

Connect your client See a real example

Browser sign-in required · Research use only

22 MCP servers · 285 tools listed in the catalog

Actual GeneFoundry result

You ask

Use GeneFoundry to look up HNF1B in gnomAD on GRCh38.

GeneFoundry returned

Loss-of-function observed / expected: 0.130 (upper bound 0.234)
pLI: 1.000

Plus five ClinVar variant records, each with its classification, review status and original source link.

Retrieved 2026-09-06 · gnomAD + ClinVar

See the result and try the prompt

Find a data source

Search by database name, data type or research area.

View all sources

gnomAD
gnomad
Research taskVariant, gene & population frequency
Listed tools22
View source
ClinVar
clinvar
Research taskVariant clinical significance
Listed tools6
View source
ClinGen
clingen
Research taskGene–disease curation
Listed tools17
View source
Human Phenotype Ontology
hpo
Research taskPhenotype ontology & associations
Listed tools17
View source
UniProt
uniprot
Research taskProtein function
Listed tools15
View source
PubTator3
pubtator
Research taskLiterature & entity annotation
Listed tools35
View source

Showing 6 of 22 catalog entries

See what you can ask

Try these prompts in a connected client. Each example explains the tool calls and source records to review.

All worked examples

What do gnomAD and ClinVar show for HNF1B?

Use GeneFoundry to look up HNF1B in gnomAD on GRCh38. Show its gene-level constraint metrics, then get five ClinVar variants sorted by review status. Include variant names, classifications, review stars and links to the original records.

View worked example

Which genes link renal cysts and diabetes?

Use GeneFoundry to find genes associated with renal cyst and diabetes mellitus in HPO, using exact terms without descendants. Retrieve every page and show the genes shared by both lists. Then check the ClinGen gene–disease validity evidence for HNF1B and link to the original curation.

View worked example

Connect your client

Choose your AI client for setup instructions.

AI client

Add GeneFoundry as a custom connector in Claude, then enable it in your conversation.

Open Customize → Connectors in Claude.
Choose + → Add custom connector. Name it GeneFoundry and enter https://genefoundry.org/mcp as the remote MCP URL.
Choose Add, then Connect if prompted. Complete the GeneFoundry sign-in in your browser.
In a new conversation, open + → Connectors and enable GeneFoundry. Paste an example prompt.

Add the endpoint below, then sign in in your browser when prompted.

Hosted MCP endpoint

https://genefoundry.org/mcp

Open Claude in your browser guide Official instructions

Setup not tested with this client.

Once you’re connected

Ask your client to discover GeneFoundry’s tools, then try a research question.

Start with a concrete example

See actual HNF1B gene and variant results

Need help?

Check the endpoint and complete any pending browser sign-in.

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