Where are HNF1B, PAX2 and GATA3 expressed?
Compare three genes across adult kidney cortex, kidney medulla and pancreas in GTEx.
Ask your AI client
Use GeneFoundry to compare HNF1B, PAX2 and GATA3 expression in GTEx v10 adult kidney cortex, kidney medulla and pancreas. Report median TPM, sample counts and the returned versioned gene IDs. Explain what bulk adult tissue expression can and cannot tell me about a developmental disease candidate.
The result
All three genes had higher median expression in the two sampled kidney tissues than in pancreas. HNF1B also had a pancreatic median of 24.401 TPM; PAX2 and GATA3 were below 1 TPM there.
| Gene | Kidney cortex (n = 104) | Kidney medulla (n = 11) | Pancreas (n = 362) |
|---|---|---|---|
| HNF1B | 57.2718 | 108.491 | 24.401 |
| PAX2 | 49.2482 | 101.601 | 0.2083 |
| GATA3 | 20.0471 | 33.7963 | 0.0933 |
| Gene | Versioned identifier |
|---|---|
| HNF1B | ENSG00000275410.6 |
| PAX2 | ENSG00000075891.23 |
| GATA3 | ENSG00000107485.18 |
TPM means transcripts per million. These tissue medians summarize different sample groups; they are not a matched-donor comparison or a statistical test of differential expression.
The medulla estimate uses only 11 samples. A higher median in this table does not establish tissue specificity or a developmental role.
Low adult expression does not exclude a gene from a congenital-disease investigation.
Original source records
How GeneFoundry got this
Compare tissue medians in one batch
Request the three gene symbols and three tissues together, fixing the dataset to GTEx v10. The expression response resolves each symbol to its versioned gene identifier.
gtex_get_median_expression_levels{ "gencode_id": [ "HNF1B", "PAX2", "GATA3" ], "tissue_site_detail_id": [ "Kidney_Cortex", "Kidney_Medulla", "Pancreas" ], "dataset_id": "gtex_v10", "response_mode": "full", "sort": "none" }
These are adult bulk-tissue RNA measurements. They do not identify the expressing cell type, describe fetal kidney development, or establish that a gene or variant causes disease.